Step-Wise Optimization of a Next Generation FcRn Inhibitor Fused to an Albumin-Binder for Improved IgG Clearance
Time: 10:00 am
day: Conference Day One
Details:
• Development of next-generation FcRn blockers with improved pharmacodynamic effects and reduced frequency of dosing could be highly beneficial for patient quality of life and patient satisfaction
• Fc-ABDEG and albumin-binding VHH were combined to develop next-generation FcRn blockers with improved IgG clearance
• Step-wise engineering was used to optimize the position and number of VHHs, their affinity to albumin, and the linker connecting it to Fc-ABDEG
