Jan Terje Andersen
Seminars
Thursday 31st July 2025
FcRn-Guided Engineering of Antibody- & Albumin-Based Formats
2:30 pm
- FcRn is a homeostatic cellular regulator of both IgG and albumin
- The importance of considering cross-species FcRn-ligand binding differences when evaluating receptor-targeting molecules in mouse models
- Design of new antibody- and albumin-based formats with tailored pharmacokinetics and effector functions
- Engineering of antibody and albumin designs with enhanced or restricted transplacental transport properties
