Vladimir Bobkov
Principal Scientist - Discovery Argenx
Seminars
Wednesday 30th July 2025
Step-Wise Optimization of a Next Generation FcRn Inhibitor Fused to an Albumin-Binder for Improved IgG Clearance
10:00 am
• Development of next-generation FcRn blockers with improved pharmacodynamic effects and reduced frequency of dosing could be highly beneficial for patient quality of life and patient satisfaction
• Fc-ABDEG and albumin-binding VHH were combined to develop next-generation FcRn blockers with improved IgG clearance
• Step-wise engineering was used to optimize the position and number of VHHs, their affinity to albumin, and the linker connecting it to Fc-ABDEG
