1:45 pm Off-the-shelf RethamTM Platelets for Assessment of Platelet Activation by Therapeutic IgG mAb Drug Candidates

1:45 pm Off-the-shelf Retham^TM Platelets for Assessment of Platelet Activation by Therapeutic IgG mAb Drug Candidates

Time: 1:45 pm
day: Conference Day One

Details:

Platelet activation induced by IgG monoclonal antibodies can significantly increase risk for adverse thrombotic events.
Evaluation of the potential for induction of platelet activation by therapeutic IgG mabs can be challenging, requiring fresh healthy-donor platelets, and sensitive activation readouts.
Long-term stored Retham^TMplatelets that have intact FcGRIIa signaling, developed using recent breakthrough technology, can be conveniently coupled to Retham’s proprietary, technically-simple ELISA for on-demand testing to de-risk therapeutic mab candidate molecules