1:45 pm Off-the-shelf RethamTM Platelets for Assessment of Platelet Activation by Therapeutic IgG mAb Drug Candidates

Time: 1:45 pm
day: Conference Day One


  • Platelet activation induced by IgG monoclonal antibodies can significantly increase risk for adverse thrombotic events.
  • Evaluation of the potential for induction of platelet activation by therapeutic IgG mabs can be challenging, requiring fresh healthy-donor platelets, and sensitive activation readouts.
  • Long-term stored RethamTM platelets that have intact FcGRIIa signaling, developed using recent breakthrough technology, can be conveniently coupled to Retham’s proprietary, technically-simple ELISA for on-demand testing to de-risk therapeutic mab candidate molecules