2:30 pm Unlocking Fc Gamma Receptors’ Power: Fine-Tuning Antibody-Based Immunotherapy Identification & Characterization of FcγRIIb Selective PD-1 Agonist mAbs
Time: 2:30 pm
day: Conference Day Two PM
Details:
- Agonist antibodies to PD-1 that mimic the function of natural ligands have the potential to suppress human autoimmune diseases and reinstate tolerance
- PD-1 agonist antibodies rely on the mediated clustering of Fc-gamma receptors (FcγRs) to elicit their suppressive function
- Seismic PD-1 agonist is a dual-cell bidirectional antibody that agonizes PD-1 and selectively binds the inhibitory FcγRIIb receptor
- Seismic PD-1 agonist inhibits T-cell activity while preventing antigen presenting cell activation
