FcRn-Guided Engineering of Antibody- & Albumin-Based Formats

• FcRn is a homeostatic cellular regulator of both IgG and albumin
• The importance of considering cross-species FcRn-ligand binding differences when evaluating receptor-targeting molecules in mouse models
• Design of new antibody- and albumin-based formats with tailored pharmacokinetics and effector functions
• Engineering of antibody and albumin designs with enhanced or restricted transplacental transport properties

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