10:00 am Severing Fc Effector Functions from Antigen Binding; IgG Proteases for Autoimmunity
Time: 10:00 am
day: Conference Day Two
Details:
- Discussing bacterial IgG protease IdeS cleaving antibodies in the hinge to decouple effector functions from antigen binding
- AI-guided removal of T cell epitopes and shielding of surface epitopes by glycoengineering to reduce Immunogenicity of IdeS
- Extending pharmacodynamics by hyperglycosylation, creating a long-lived deimmunized IgG protease for deactivation and depletion of IgG autoantibodies
