10:00 am Severing Fc Effector Functions from Antigen Binding; IgG Proteases for Autoimmunity

Time: 10:00 am
day: Conference Day Two

Details:

  • Discussing bacterial IgG protease IdeS cleaving antibodies in the hinge to decouple effector functions from antigen binding
  • AI-guided removal of T cell epitopes and shielding of surface epitopes by glycoengineering to reduce Immunogenicity of IdeS 
  • Extending pharmacodynamics by hyperglycosylation, creating a long-lived deimmunized IgG protease for deactivation and depletion of IgG autoantibodies

Speakers: